ADH1 — Aspergillus nidulans FGSC A4

Summary

AnADH1 (ANIA_08979) on chromosome 7 of Aspergillus nidulans FGSC A4 encodes an alcohol dehydrogenase (EC 1.1.1.1) with aldo-keto reductase (NAD) activity, containing ADH-like and rhodanese-like domains. The gene is associated with ethanol fermentation, acetaldehyde, ethanol and threonine breakdown, carbohydrate metabolism, aflatoxin anabolism, and cellular response to farnesol. It has been linked to the fungal biofilm matrix, cytoplasm, mitochondrial lumen, and extracellular localisation. Related genes in other species, including Fusarium oxysporum and Verticillium dahliae, are linked by sequence similarity, though these associations are not yet established for AnADH1 itself.