BET3 — Aspergillus nidulans FGSC A4

Summary

AnBET3 (ANIA_09086) on chromosome 6 of Aspergillus nidulans FGSC A4 encodes a TRAPP component with a NO_sig/Golgi_transp_ligand-bd domain. The gene is associated with intra-Golgi and ER-to-Golgi transport, macroautophagy, and intracellular protein transport. Its product localises to the cis-Golgi network membrane, the TRAPP complex, the ER, cytosol, and nucleus. AnBET3 is associated with decreased autophagy and pexophagy rates, absent protein transport, abnormal Golgi morphology, arrested mitotic cell cycle, delayed and decreased meiosis, abnormal endocytosis, bud neck and mating projection morphology, chitin deposition, spore wall formation, protein secretion, and cytokinesis. It is also associated with increased nutrient uptake, decreased intracellular transport and cell cycle progression, and abnormal S-phase progression. Related genes in other species connect the family to the TRAPP core, TRAPPII, and TRAPPIII complexes.