GST1 — Aspergillus nidulans FGSC A4

Summary

ANIA_09299 (GST1, AnGST1) on chromosome 8 of Aspergillus nidulans encodes a glutathione transferase with glutathione peroxidase activity, phosphoprotein binding, and transcription corepressor activity. The product localises to the cytoplasm, cytosol, and nucleus. The gene is associated with cellular detoxification, nitrate assimilation, regulation of nitrogen utilisation, protein urmylation, protein localisation, and negative regulation of RNA polymerase II transcription. Phenotypic associations include abnormal mating-type switching, increased cell cycle progression rate, decreased hypoosmotic stress resistance, increased nutrient and carbon source utilisation, increased fermentative growth, abnormal respiratory metabolism, decreased adhesion, increased entry into G0 stationary phase, and sterility. Studies of related genes in other species link the family to oxidative stress response, calcium sensitivity, and phosphate content.