ARP1 — Aspergillus nidulans FGSC A4

Summary

ANIA_10049 (ARP1, also known as AnARP1 or SDH1) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a scytalone dehydratase, a lyase with metal-binding activity that belongs to the scytalone dehydratase and NTF2-like domain superfamilies. The gene is associated with melanin metabolism and pigmentation, including melanin and pigment biosynthesis, as well as xanthones and monodictyphenone anabolism. It has also been linked to nuclear transport, mitotic spindle assembly, microtubule assembly, intracellular transport, nuclear movement, RNA splicing, and endosome localisation. Related genes in other species are linked to scytalone dehydratase activity (EC 4.2.1.94) and to loss of pathogenicity and reduced virulence.