PDH — Aspergillus nidulans FGSC A4

Summary

ANIA_10488 (PDH) on chromosome 2 of Aspergillus nidulans FGSC A4 encodes a cellobiose dehydrogenase (acceptor) activity enzyme, a member of the GMC oxidoreductase family with a cellobiose dehydrogenase cytochrome domain. The product possesses cellulose-binding, FAD/FADH2-binding, redox, and metal-binding capabilities and is secreted extracellularly. This gene is associated with cellulose breakdown, carbon catabolite repression, and carbohydrate metabolism, as well as pyruvate and acetate metabolism, the glyoxylate cycle, and the TCA cycle. Studies of related genes in other species link the family to cellobiose dehydrogenase (EC 1.1.99.18) activity, though this is not yet established for PDH itself. The gene is related to cdh-1 and cdh-2.