CLM2 — Aspergillus nidulans FGSC A4

Summary

ANIA_10776 (symbol CLM2, preferred name AnCLM2) in Aspergillus nidulans FGSC A4 encodes a cytochrome P450 monooxygenase with heme and iron binding, oxidoreductase activity acting on paired donors with oxygen incorporation, and belongs to the fungal cytochrome P450 family. This gene is associated with ergosterol, patulin, mycotoxin, terpenoid, and secondary metabolite biosynthesis, as well as lipogenesis, fermentation, sexual reproduction, meiosis, endocytosis, autophagy, and hypersensitivity. It is linked to the endoplasmic reticulum membrane. Phenotypic associations include decreased micronucleophagy, ribophagy, and shmoo formation; increased cell death and G2/M phase transition; abnormal cell cycle progression, cytokinesis absence, and vegetative growth arrest; altered carbon and iron source utilization; and increased lifespan. Studies of related genes in other species connect the family to sterol biosynthesis (ERG11, ERG24, ERG4, ERG28, ERG9) and protein content traits.