uaY — Aspergillus nidulans FGSC A4

Summary

ANIA_10976 (uaY) on chromosome 4 of Aspergillus nidulans FGSC A4 encodes a Zn(II)2Cys6 transcription factor, a member of the Zn2Cys6 DNA-binding domain family. The product has DNA-binding transcription repressor activity specific to RNA polymerase II and is associated with sequence-specific DNA binding. This gene is linked to a wide range of biological processes, including hypoxanthine transport, purine base breakdown, pigmentation, response to ammonia, cellular response to oxidative stress, endocytosis, and both positive and negative regulation of transcription by RNA polymerase II. It is also connected to gene conversion, methylation, and translation termination. The protein localises to the nucleus, cytoplasm, cytosol, membrane, and nuclear inner membrane. Studies of related genes in other species link the family to xylanolytic transcriptional regulation.