TMS1 — Aspergillus nidulans FGSC A4

Summary

AnTMS1 (ANIA_11244) on chromosome 1 of Aspergillus nidulans FGSC A4 encodes a putative membrane protein of the TDE1/TMS family with phospholipid scramblase activity. The gene is associated with xanthine and urate transport, phosphatidylserine metabolism, and sphingolipid anabolism. Its product localizes to the plasma membrane, endosome, fungal-type vacuole membrane, lipid raft, and general membrane. Phenotypic associations link AnTMS1 to numerous cellular processes: absent micronucleophagy and vacuolar transport, increased small molecule transport and nutrient utilization, decreased duration of cell cycle progression in G1 phase and increased rate of growth in exponential phase, decreased acquired thermotolerance, autophagy, reticulophagy, and protein secretion, abnormal colony and subcellular morphology, increased biofilm formation and chitin deposition, absent sporulation and carbon source utilization, and abnormal lipid particle morphology. The gene is also connected to ESCRT-III complex components including VPS68, VPS60, DID4, VPS24, and SNF7.