GEA1 — Aspergillus nidulans FGSC A4

Summary

ANIA_00112 (symbol GEA1, also known as AnGEA1 or GEA2) on chromosome 8 encodes a putative guanine nucleotide exchange factor (Gea2) containing a Sec7 domain and a GBF1-like TPR region. The encoded protein is associated with metal binding. AnGEA1 is associated with ER-to-Golgi and intra-Golgi transport, Golgi-to-plasma membrane protein transport, regulation of ARF protein signal transduction, actin cytoskeleton organization, and signaling. The protein localizes to Golgi membranes, COPI and COPII coated vesicle membranes, and the cytoplasm. Phenotypic associations include delayed protein secretion and vegetative growth, abnormal Golgi morphology, decreased cell cycle progression, absent spore germination, abnormal endocytosis and chitin deposition, increased nutrient uptake, and decreased cell death. Studies of related genes in other species link the GEA1 family to cell cycle regulation.