palB — Aspergillus nidulans FGSC A4

Summary

ANIA_00256 (symbol palB) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a calpain-like cysteine protease, containing calpain domain III, a MIT domain, and a peptidase C2 catalytic domain, with calcium-dependent cysteine-type endopeptidase activity (EC 3.4.22.-). The gene is associated with sex determination, mating, chlamydospore formation, filamentous and hyphal growth, fermentation, secretion, host invasion, and regulation of secondary metabolite biosynthesis, including activation of penicillin anabolism. It is also linked to cellular responses to pH, nutrients, and xenobiotic stimuli, as well as nonsense-mediated mRNA decay, RNA splicing, and gene expression regulation. The product localises to the ESCRT III complex. Related genes in other species include calpain-7 proteases.