AOX1 — Aspergillus nidulans FGSC A4

Summary

ANIA_00567 (AOX1) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a glucose-methanol-choline oxidoreductase N-terminal domain-containing protein, a member of the GMC oxidoreductase family with FAD/NAD-binding domains. The enzyme exhibits alcohol oxidase activity, pyranose dehydrogenase (acceptor) activity, and broader oxidoreductase activity acting on CH-OH group donors, along with lipid binding and FAD or FADH2 binding. It is associated with methane breakdown, methanol metabolism, polyketide anabolism, and secretion, and localizes to the peroxisomal lumen and extracellular space. Related genes in other species link the family to alcohol oxidase (EC 1.1.3.13) and pyranose dehydrogenase (EC 1.1.99.29) activities.