ATRR — Aspergillus nidulans FGSC A4

Summary

ANIA_00618 (ATRR) on Aspergillus nidulans chromosome 8 encodes an oxidoreductase with acylglycerone-phosphate reductase (NADP+) activity, belonging to the short-chain dehydrogenase/reductase (SDR) family. The gene is associated with triglyceride breakdown, phosphatidic acid anabolism, ergosterol anabolism, secondary metabolite biosynthesis, and biofilm formation. Its product localises to the endoplasmic reticulum, adiposome, membrane, cytoplasm, and nucleus. Phenotypic associations link ATRR to decreased vegetative growth rate, competitive fitness, and replicative lifespan, as well as increased telomere length and mutation frequency. The gene is also linked to abnormal cell cycle progression through G2/M phase, decreased thermotolerance and desiccation resistance, and altered prion inheritance. Studies of related genes in other species link the SDR family to increased transposable element transposition and chronological lifespan.