CAT8 — Aspergillus nidulans FGSC A4

Summary

ANIA_00689 (CAT8, AnCAT8) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a Zn(2)-C6 fungal-type domain-containing protein with DNA-binding transcription repressor activity specific to RNA polymerase II. This transcription factor is associated with acetate response, transport, and breakdown, as well as fatty acid beta-oxidation, the glyoxylate cycle, gluconeogenesis, the TCA cycle, and carbon catabolite repression. It has also been linked to filamentous growth in response to biotic stimuli, fruiting body formation, protein acetylation, and heterotrophy. The protein localises to the membrane, cytosol, and nucleus. Studies of related genes in other species link the family to reduced virulence and pulmonary aspergillosis.