ADB — Aspergillus nidulans FGSC A4

Summary

The Aspergillus nidulans gene ANIA_00893 (AnADB) on chromosome 8 encodes an adenylosuccinate synthetase (EC 6.3.4.4), an enzyme associated with the de novo AMP biosynthetic process and IMP metabolism. The encoded protein binds GMP, AMP, GTP and magnesium. AnADB is localised to the cytoplasm and is associated with cellular response to cadmium, hypersensitivity and chromatin modelling. Phenotypic associations link the gene to increased rates of nutrient uptake, carbon-source utilisation and fermentative metabolism, as well as altered adhesion, flocculation, sporulation efficiency, filamentous growth, telomere length, prion dynamics, cell-cycle progression, and resistance to alkaline pH, hydrostatic pressure and killer toxin. Studies of related genes in other species connect the adenylosuccinate synthetase family to abnormal colony colour, chemical excretion, spore germination and lipid particle morphology.