GPAB — Aspergillus nidulans FGSC A4

Summary

ANIA_01016 (GPAB, ganB) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a G-protein alpha subunit. The gene product is associated with adenylate cyclase activator activity, G protein-coupled receptor binding, and G-protein beta/gamma-subunit complex binding. It is linked to the heterotrimeric G-protein complex and cytoplasm, and has been connected to numerous biological processes including cAMP anabolism, GPCR signaling, carbon catabolite repression, response to glucose, negative regulation of conidium formation, asexual sporulation, spore germination, sexual reproduction, autolysis, digestion, and toxin anabolism. The gene is also associated with germination rate. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence.