CHSD — Aspergillus nidulans FGSC A4

Summary

ANIA_01046 (CHSD, AnCHSD) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a chitin synthase with chitin synthase activity (EC 2.4.1.16). The product also exhibits cytoskeletal motor activity, actin binding, and ATP binding, and localises to the apical plasma membrane, chitosome, myosin complex, and cellular bud neck. AnCHSD is associated with conidiophore development, asexual sporulation, ascospore wall assembly and formation, conidia formation, hyphal growth, cell wall organisation, and regulation of chitin anabolism. It is linked to protein localisation to the bud neck, cell growth, and morphogenesis. Studies of related genes in other species connect the family to polysaccharide content and both unaffected and reduced virulence, though these associations are not established for AnCHSD itself.