ARF1 — Aspergillus nidulans FGSC A4

Summary

ANIA_01126 (AnARF1, also known as ARF1 or ARF2) on Aspergillus nidulans chromosome 8 encodes a small GTPase of the Arf1-5-like family with GTPase activity, GTP binding, and protein membrane adaptor functions. The gene is associated with ER-to-Golgi transport, vesicle organization, exocytosis, secretion, and intracellular protein transport, as well as positive regulation of mitotic entry and cell growth mode switching from monopolar to bipolar. It is linked to mitochondrial fission and membrane organization, nuclear envelope organization, tubulin assembly, and cellular responses to xenobiotic and oxidative stress. The protein localizes to the Golgi membrane, COPII vesicle coat, ER exit sites, microtubule cytoskeleton, division septum, and cell cortex. Phenotypic associations include absent sporulation and spore germination, delayed vegetative growth, arrested cell cycle progression, abnormal Golgi morphology, and decreased cell death. Related genes in other species are linked to reduced virulence.