PRS — Aspergillus nidulans FGSC A4

Summary

ANIA_01201 (PRS, AnPRS) on Aspergillus nidulans chromosome 8 encodes a prolyl-tRNA synthetase, an enzyme with proline-tRNA ligase activity and ATP binding that catalyses prolyl-tRNA aminoacylation. The gene is associated with mitochondrial translation, cytokinesis, sporulation, hyphal growth, and the SIN pathway, and its product localises to mitochondria and the mitochondrial lumen. AnPRS is associated with abnormal RNA localisation and nucleolar morphology, increased nucleolar size, increased filamentous growth, heat sensitivity, haploinsufficiency, inviability, decreased vegetative growth and competitive fitness, and decreased chemical resistance. Studies of related genes in other species connect the prolyl-tRNA synthetase family to abnormal mitochondrial genome maintenance, altered stress and metal resistance, decreased respiratory growth, and changes in cell size, lipid particle morphology, and vacuolar morphology.