DLH1 — Aspergillus nidulans FGSC A4

Summary

ANIA_01237 (DLH1, also known as AnDLH1, AnRAD51, AnDMC1, or AnMEI-3) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a RecA-family recombinase with ATPase activity, DNA binding, and Sae3-Mei5 complex binding. The gene is associated with meiotic strand invasion, heteroduplex formation, double-strand break repair during meiotic recombination, DNA recombinase assembly, and stalled replication fork localization to the nuclear periphery. It localizes to condensed nuclear chromosomes, the centromere complex, sites of double-strand breaks, and the nuclear envelope. Phenotypic associations include absent sporulation efficiency, absent X-ray resistance, absent mitotic recombination, abnormal spore germination, delayed chromosome segregation, and altered cell cycle progression through G1/S and metaphase-anaphase transitions. Related genes in other species link the family to oxidative stress response.