PST1 — Aspergillus nidulans FGSC A4

Summary

AnPST1 (ANIA_01546) on chromosome 7 of Aspergillus nidulans FGSC A4 encodes a putative Sin3-like transcription factor containing PAH domains and an HDAC interaction domain, with transcription corepressor activity and bridging binding functions. The gene is associated with diverse nuclear processes including chromatin-mediated transcription, centromeric silencing, mating type switching, meiosis, NHEJ, autophagy, cell death, and cell division. It localises to chromatin, the nucleus, cytosol, and the Clr6-LE complex. Phenotypic associations link AnPST1 to altered cell cycle progression, abnormal mating type switching, increased virulence, delayed fermentative metabolism, increased nutrient uptake, premature RNA and protein accumulation, and abnormal pheromone sensitivity and nuclear export. Studies of related genes in other species connect the SIN3 family to the Rpd3S and Rpd3C(L) complexes.