NOSA — Aspergillus nidulans FGSC A4

Summary

ANIA_01848 (symbol NOSA, also known as ADV-1) on chromosome 7 of Aspergillus nidulans FGSC A4 encodes a Zn2Cys6 fungal-type DNA-binding domain transcription factor with RNA polymerase II-specific transcription factor activity, DNA binding, and zinc binding. It is localized to the nucleus. This gene is associated with fruiting body formation, cleistothecium development, ascospore formation, and mycotoxin anabolism, specifically sterigmatocystin biosynthesis, as well as secondary metabolism, protein secretion, proteolysis, and homeostasis. It has also been linked to germination rate. Related genes in other species encode Zn(2)-C6 fungal-type domain-containing proteins, though these associations are not yet established for NOSA itself.