aceA — Aspergillus nidulans FGSC A4

Summary

ANIA_01924 (aceA) on chromosome 7 encodes a copper fist DNA-binding domain protein. The gene is associated with copper ion homeostasis, cellular iron ion homeostasis, pigmentation, detoxification, immune evasion, and regulation of superoxide removal. It has been linked to copper concentration and copper sensitivity traits. The encoded protein localises to the nucleus, cytoplasm, cytosol, chromatin, and cell cortex. Studies of related genes in other species link the family to reduced virulence and invasive pulmonary aspergillosis, though pathogenicity is unaffected in some relatives.