MPR1 — Aspergillus nidulans FGSC A4

Summary

ANIA_02005 (MPR1, also known as ypdA) on chromosome 7 of Aspergillus nidulans encodes a protein in the AHP1-5/YPD1 family with histidine kinase binding activity, transferase activity transferring phosphorus-containing groups, histidine phosphotransfer kinase activity, and phosphorelay sensor kinase activity. The gene is associated with the histidyl-aspartyl phosphorelay, osmolarity sensing via a two-component system, activation of the p38 MAPK cascade, regulation of cellular response to oxidative stress, GABA catabolism, asexual reproduction and sporulation, detoxification, and signal transduction. Its product localises to the cytoplasm, cytosol, and nucleus. Phenotypic associations include decreased hyperosmotic stress resistance, abnormal chromosome segregation and spindle morphology, delayed cell cycle progression in M and S phases, decreased vegetative growth and competitive fitness, and inviability. Studies of related genes in other species link the family to oxidative stress response.