THO2 — Aspergillus nidulans FGSC A4

Summary

ANIA_02226 (AnTHO2, THO2) on chromosome 7 encodes the THO complex subunit 2, a protein containing THOC2_N and THO_THOC2_C domains. The gene product binds mRNA and DNA and localises to the nucleus. AnTHO2 is associated with mRNA processing, nuclear export of poly(A)+ mRNA, nuclear transport and import, nuclear movement, DNA-dependent transcription, interphase and mitosis. Phenotypic associations link the gene to decreased utilisation of sulphur and phosphorus sources, absent UV resistance, decreased anaerobic growth, abnormal mitotic cell cycle, delayed or decreased meiosis, absent meiotic recombination, decreased chromosome segregation, increased G1 phase progression and increased S phase duration, decreased exponential-phase growth, absent mating response, decreased pheromone production and cell cycle arrest, abnormal cell size, decreased ribophagy, and decreased chemical compound excretion. Studies of related genes in other species connect the THO family to the TREX complex and oxidative stress response.