CDC11 — Aspergillus nidulans FGSC A4

Summary

ANIA_02459 (symbol CDC11, preferred name AnCDC11) on chromosome 7 of Aspergillus nidulans FGSC A4 encodes a conserved leucine-rich repeat protein with signaling adaptor activity. The gene is associated with the septation initiation network (SIN) and the regulation of mitotic cytokinesis, including activation of mitotic division septum assembly. It has been linked to cell cycle progression, mitosis, mitotic telophase, interphase, cytokinesis, cell division, morphogenesis, and pigmentation. The product localises to the SIN/MEN signaling complex, the outer plaque of the mitotic spindle pole body, the meiotic spindle pole body, and the cytoplasm. Studies of related genes in other species link the family to septation initiation network scaffold function and, more distantly, to protein content traits.