CASB — Aspergillus nidulans FGSC A4

Summary

ANIA_02503 (CASB, AnCASB) on chromosome 7 encodes metacaspase-1B, a thiol endopeptidase belonging to the metacaspase family. This gene is associated with apoptotic process, autophagy, cell death, proteolysis, mating, mating type switching, and meiosis, and its product localizes to the cytoplasm. Phenotypic associations include abnormal carbon source utilization, increased necrotic cell death, delayed sporulation, increased polyploidy, abnormal pseudohyphal growth and colony shape, altered cell cycle progression through G1/S and G2/M transitions, increased budding, decreased respiratory metabolism, and increased fermentative metabolism. Studies of related genes in other species link the family to oxidative stress response.