easC — Aspergillus nidulans FGSC A4

Summary

ANIA_02548 (easC) on chromosome 7 of Aspergillus nidulans FGSC A4 encodes a protein with a CAT-like domain superfamily and acyltransferase activity (EC 2.3.1.-), also annotated for transferase activity, metal binding, and pigment binding. The gene is associated with the biosynthesis of several alkaloids, including emericellamide A, ergot alkaloids, and fumigaclavine C, as well as alkaloid anabolism. Sequence-similarity studies of related genes in other species link the easC family to the production of diverse secondary metabolites such as T-2 toxin (via TRI101) and pigments (via clz6, pigD, and others), though these functions are not established for A. nidulans itself.