HIS2 — Aspergillus nidulans FGSC A4

Summary

ANIA_02723 (HIS2, AnHIS2) on chromosome 6 encodes a histidinol dehydrogenase with phosphoribosyl-ATP diphosphatase, phosphoribosyl-AMP cyclohydrolase and histidinol dehydrogenase activities (EC 1.1.1.23), and binds NAD, ATP and metal ions. The gene is associated with histidine anabolism and nicotinate breakdown, and its product localises to the cytoplasm and cytosol. AnHIS2 is associated with asexual reproduction, and numerous phenotypes including abnormal cell cycle progression (S-phase arrest and G2/M arrest), decreased osmotic stress resistance, decreased acquired thermotolerance, altered sporulation efficiency, abnormal budding and chromosome segregation, increased pseudohyphal growth, decreased pexophagy and reticulophagy, abnormal silencing, and absent mitochondrial genome maintenance. Related genes in other species are linked to heat sensitivity.