RLMA — Aspergillus nidulans FGSC A4

Summary

ANIA_02984 (RLMA, AnRLMA) on chromosome 6 of Aspergillus nidulans FGSC A4 encodes a MADS-box domain-containing protein with DNA-binding transcription factor activity, RNA polymerase II-specific. It binds cis-regulatory regions and bends DNA, and dimerizes. This gene is associated with conidiophore development, filamentous growth, pseudohyphal growth regulation, cell adhesion, flocculation, autolysis, cell wall biogenesis, cell cycle, signal transduction, stress and DNA damage responses, and positive regulation of transcription by RNA polymerase II. The protein localizes to the nucleus, nuclear envelope, chromatin, and cytosol. It is also linked to oxidative stress response. Studies of related genes in other species connect the gene family to loss of pathogenicity and reduced virulence.