CAG1 — Aspergillus nidulans FGSC A4

Summary

ANIA_03090 (CAG1) on Aspergillus nidulans chromosome 6 encodes a fungal G-protein alpha subunit, characterised by Fungi_Gprotein_alpha, GproteinA_insert, Gprotein_alpha_su and P-loop_NTPase domains. The product binds GTP, interacts with G-protein-coupled receptors and G-protein beta/gamma-subunit complexes, and binds metal ions. CAG1 is associated with heterotrimeric G-protein complex localisation, cortical dynamic polarity patches and the cytoplasm. It is linked to perithecium development, sexual reproduction, sporocarp development, developmental induction, asexual sporulation, spore germination, appressorium formation, pigmentation, regulation of sterigmatocystin biosynthesis, toxin and penicillin anabolism, receptor internalisation, GPCR signalling, negative regulation of the pheromone response MAPK cascade, and regulation of conidium formation. Phenotypic associations include altered mating efficiency, abnormal mating response, abnormal pheromone sensitivity, increased shmoo formation, delayed sporulation, increased pexophagy, and altered cell cycle progression.