HMT1 — Aspergillus nidulans FGSC A4

Summary

ANIA_03096 (HMT1, AnHMT1) on Aspergillus nidulans chromosome 6 encodes a protein arginine methyltransferase (PRMT) with a PRMT domain, a C2H2 zinc finger, and SAM-dependent methyltransferase activity. The enzyme catalyzes histone H4KR3 methylation and exhibits protein arginine omega-N asymmetric methylase and monomethylase activities. AnHMT1 is associated with protein methylation, chromatin remodeling, regulation of DNA-templated transcription, ribosome biogenesis, secondary metabolism including mycotoxin biosynthesis, membrane transport, and morphogenesis. The protein localizes to the cytoplasm, cytosol, and nucleus. Phenotypic associations link the gene to increased virulence, decreased lifespan, abnormal sporulation and mating efficiency, premature cell cycle progression, and abnormal pseudohyphal growth.