GCS1 — Aspergillus nidulans FGSC A4

Summary

ANIA_03150 (GCS1, AnGCS1) on chromosome 6 of Aspergillus nidulans FGSC A4 encodes a glutamate-cysteine ligase (EC 6.3.2.2) with ATP-binding activity. The gene is associated with glutathione metabolism and anabolism, phytochelatin anabolism, cellular detoxification of cadmium ion, response to cadmium and hydrogen peroxide, redox sensing, and DNA repair. The product localises to the cytoplasm, cytosol, nucleus and glutamate-cysteine ligase complex. Phenotypic associations include absent oxidative stress resistance and desiccation resistance, decreased spore germination rate, delayed sporulation and cell-cycle progression, and altered nutrient uptake and nitrogen utilisation. Related genes in other species link the family to oxidative stress response.