ADH — Aspergillus nidulans FGSC A4

Summary

ANIA_03312 (ADH) on chromosome 6 of Aspergillus nidulans FGSC A4 encodes a member of the short-chain dehydrogenase/reductase (SDR) family, an oxidoreductase with NADP-dependent activities including L-xylulose reductase, carbonyl reductase, sorbose reductase and mannitol 2-dehydrogenase. The gene is associated with carbon catabolite repression, catabolite repression, and the metabolism of xylulose, L-sorbose, mannitol, ethanol, glucose, and other carbohydrates. It has also been linked to secondary metabolite biosynthesis, translation initiation, and protein homotetramerization. The encoded protein localises to the vacuole. Studies of related genes in other species link the family to additional NADP-dependent oxidoreductase activities (EC 1.1.1.10, 1.1.1.138, 1.1.1.184, 1.1.1.289).