laeA — Aspergillus nidulans FGSC A4

Summary

ANIA_03556 (laeA) on chromosome 2 of Aspergillus nidulans FGSC A4 encodes an ABC transmembrane type-1 domain-containing protein with ATP-coupled transporter activity, ATP binding and hydrolase activity, and methyltransferase activity. The gene is associated with the biosynthesis of numerous secondary metabolites, including diorcinol, PR-toxin, penicillin G, gliotoxin, terrequinone A, carotene, and carotenoids. It is also linked to developmental processes such as asexual and sexual sporulation, fruiting body formation, perithecium development, pigmentation, and stem cell differentiation. The encoded protein localises to the plasma membrane, membrane, and nucleus. Additionally, laeA is associated with germination rate and oxidative stress response. Related genes in other species are linked to methyltransferase activity.