CPCA — Aspergillus nidulans FGSC A4

Summary

ANIA_03675 (symbol CPCA, also known as AnCPCA or CPC-1) on chromosome 2 of Aspergillus nidulans FGSC A4 encodes a bZIP domain-containing protein with DNA-binding transcription factor activity, specifically RNA polymerase II cis-regulatory region sequence-specific DNA binding. This gene is associated with the regulation of , including histidine and cysteine anabolism, as well as the upregulation of cellular response to amino acid starvation and nitrogen catabolite activation of transcription. It has been connected to carbon catabolite repression, penicillin anabolism, secondary metabolite biosynthesis, sporulation, nuclear transport, and cell division. The encoded protein localizes to the nucleus and transcription regulator complex. Studies of related genes in other species link the family to reduced virulence.