PRR1 — Aspergillus nidulans FGSC A4

Summary

ANIA_03688 (PRR1, srrA) on chromosome 2 of Aspergillus nidulans FGSC A4 encodes a phosphorelay response regulator with DNA-binding transcription activator activity specific for RNA polymerase II, containing a heat shock factor DNA-binding domain and a signal transduction response regulator receiver domain. The gene is associated with carbohydrate utilization, response to singlet oxygen, regulation of the unfolded protein response, cellular thermotolerance, autolysis, conidiophore development, germ tube formation, asexual reproduction and sporulation, osmolarity sensing via the two-component system, histidyl-aspartyl phosphorelay, and the high-osmolarity glycerol response. It is linked to oxidative stress response, pH response, and numerous phenotypes including altered flocculation, biofilm formation, spore germination, cell cycle progression, mating efficiency, filamentous growth, and carbon source utilization. The protein localizes to the nucleus, cytoplasm, chromatin, and RNA polymerase II transcription regulator complex.