DO — Aspergillus nidulans FGSC A4

Summary

ANIA_03729 (AnDO) encodes a protein with FKS1-like domains and a Glyco_trans_48 domain, and is annotated with branched 1,3-beta-D-glucan synthase activity, callose synthase activity, and alpha-1,3-glucan synthase activity (EC 2.4.1.34). The gene is associated with fungal-type cell wall polysaccharide biosynthesis, primary and secondary cell septum biogenesis, ascospore wall 1,3-beta-glucan anabolism, and mitotic division septum assembly. It localizes to the 1,3-beta-glucan synthase complex, primary cell septum, spore wall, hyphal tip, and sites of polarized growth. AnDO is linked to cell cycle progression through the G2/M phase transition, spore germination rate, budding, shmoo formation, alkaline pH resistance, and fermentative growth. Studies of related genes in other species connect the family to sporogenesis, beta-glucan content, turgor pressure, and oxidative stress response. The gene also associates with cell wall organization, conjugation with cellular fusion, and digestion.