MIH1 — Aspergillus nidulans FGSC A4

Summary

ANIA_03941 (MIH1, nimT) on chromosome 2 of Aspergillus nidulans FGSC A4 encodes a protein tyrosine phosphatase (EC 3.1.3.48) with a rhodanese-like domain and an MPI_Phosphatase family domain. The gene is associated with the positive regulation of the G2/MI transition of the meiotic cell cycle, mitotic entry, and the G2/M transition, as well as with cell cycle checkpoints, including the response to mitotic G2 DNA damage checkpoint signaling and the intra-S DNA damage checkpoint. It is also linked to protein methylation, protein kinase A activation, spore germination, nuclear movement, and cell size control. The product localizes to the cytoplasm, cytosol, and nucleus. Studies of related genes in other species link the family to traits such as root width, cell membrane stability, leaf shape, and protein content.