GLN1 — Aspergillus nidulans FGSC A4

Summary

ANIA_04159 (GLN1, AnGLN1) on chromosome 2 of Aspergillus nidulans encodes a glutamine synthetase (EC 6.3.1.2) with ATP-binding activity, featuring conserved Gln_synth_N and catalytic domains. This enzyme is associated with L-glutamine biosynthesis and the ammonia assimilation cycle, and is linked to nitrate assimilation, response to nitrite, and vitamin B6 and A metabolism. The gene product localises to the cytoplasm, cytosol and nuclear periphery, and is linked to hyphal growth, asexual sporulation, and appressorium formation. Phenotypic associations include decreased osmotic stress resistance, abnormal autophagy, absent mitophagy and endocytosis, altered pseudohyphal and invasive growth, increased vegetative growth, and reduced gamma ray resistance. Studies of related glutamine synthetase sequences in other fungi connect the family to nitrogen metabolism and stress responses, though these functions are not established for AnGLN1 itself.