ARG3 — Aspergillus nidulans FGSC A4

Summary

ANIA_04409 (ARG3, argB) on chromosome 3 of Aspergillus nidulans encodes a protein with ornithine carbamoyltransferase, aspartate carbamoyltransferase, carbamoyl-phosphate synthase (ammonia and glutamine-hydrolyzing), and glutaminase activities, and belongs to the aspartate/ornithine carbamoyltransferase superfamily. The gene is associated with the urea cycle, citrulline, histidine, lysine, and pyrimidine biosynthesis, glutamine metabolism, penicillin anabolism and its regulation, conidiophore development, asexual sporulation, nitrate assimilation, DNA-mediated transformation and integration, recombinational repair, and the glucose effect. The encoded protein localises to the cytoplasm, cytosol, nucleus, mitochondria, and mitochondrial lumen. Phenotypic associations include increased freeze-thaw resistance and lifespan, decreased cell death rate, altered nutrient uptake, respiratory metabolism, mitochondrial transport and genome maintenance, cell cycle delay, increased sporulation efficiency, and decreased pseudohyphal growth, stationary phase survival, and acquired thermotolerance.