RPL11 — Aspergillus nidulans FGSC A4

Summary

ANIA_04475 (AnRPL11) encodes the 60S ribosomal protein L11, a structural constituent of the ribosome with rRNA-binding and RNA-binding activity. Located in the cytoplasm, nucleus, and fungal biofilm matrix, it is associated with translation, cytoplasmic translation, ribosome biogenesis, and rRNA processing. This gene has been linked to numerous phenotypes including abnormal fermentative metabolism, increased and decreased adhesion, absent and abnormal meiosis, altered nutrient uptake, decreased nitrogen source utilization, decreased cold sensitivity, increased desiccation resistance, increased vegetative growth rate, delayed G1/S phase transition, abnormal budding, decreased pseudohyphal growth, decreased gamma ray resistance, increased viability, altered prion formation and loss, abnormal cytoskeleton and nuclear morphology, and G2/M phase arrest. Related genes in other species connect it to ribosome assembly factors such as RRS1, BUD20, and SDO1.