ASPA — Aspergillus nidulans FGSC A4

Summary

ANIA_04667 (AnASPA) encodes a septin-type G domain-containing protein with GTPase activity and structural constituent of cytoskeleton function, and is annotated to bind phosphatidylinositol phosphates. AnASPA is associated with mitotic telophase, cytokinesis, septin ring assembly and disassembly, conidiophore development, pigmentation, cell polarity maintenance, and chitin localization. The gene is linked to cell cycle progression, including G2/M phase transition, metaphase-anaphase transition, and telophase arrest, as well as increased fermentative growth, abnormal prion inheritance, and decreased nucleophagy. AnASPA localizes to the septin cytoskeleton, bud neck septin structure, and hyphal septin rings. Related genes in other species link the family to virulence and pathogenicity in aspergillosis and candidiasis.