ABCA — Aspergillus nidulans FGSC A4

Summary

ANIA_04749 (symbol ABCA, preferred name AnABCA) on chromosome 3 of Aspergillus nidulans FGSC A4 encodes an ABC transporter domain-containing protein with ATP hydrolase activity and ATP binding. This ABC transporter is associated with demethylation, response to toxic substances, and xenobiotic detoxification by transmembrane export across the plasma membrane. It localises to the plasmalemma and membrane. The gene is linked to abnormal small molecule transport, increased sporulation rate, decreased cell death rate, delayed mitophagy, and altered nutrient uptake, vacuolar distribution, and cell cycle progression. Studies of related genes in other species connect the family to reduced virulence and unaffected pathogenicity.