PPOA — Aspergillus nidulans FGSC A4

Summary

ANIA_05028 (PPOA, AnPPOA) on chromosome 3 of Aspergillus nidulans FGSC A4 encodes an uncharacterized protein that contains a Ppo-like N-terminal domain and belongs to the animal haem peroxidase superfamily, with predicted fatty acid peroxidase, linoleate 8R-lipoxygenase, 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase, dioxygenase, isomerase, monooxygenase, and oxidoreductase activities, and binds iron and heme. The gene is associated with oxylipin, prostaglandin, and phytosphingosine biosynthesis, long-chain fatty acid metabolism, cell wall thickening, regulation of hypersensitivity, and both positive and negative regulation of asexual and sexual sporulation. It is also linked to fruiting body formation, sterigmatocystin and penicillin metabolism, and carboxylic acid biosynthesis. Related genes in other species are associated with altered virulence.