NUD3 — Aspergillus nidulans FGSC A4

Summary

ANIA_05181 (NUD3, nudC) on chromosome 5 of Aspergillus nidulans FGSC A4 encodes a protein containing a NudC family domain, a CS domain, and an HSP20-like chaperone domain, with molecular function annotated as GO:0051082 (unfolded protein binding). The gene is associated with a wide range of biological processes, including response to growth factor, lateral root development, cotyledon development, root development, neurogenesis, interkinetic nuclear migration, ciliogenesis, oogenesis, cell migration, brain development, microtubule destabilization, nuclear migration along microtubule, inflammatory response, and microtubule-based movement. It is also linked to the trait root length. The encoded protein localizes to the microtubule, cytoplasm, and nucleus. Studies of related genes in other species link the NUDC family to lethal phenotypes and invasive pulmonary aspergillosis.