DIS1 — Aspergillus nidulans FGSC A4

Summary

ANIA_05521 (DIS1, also known as alpA) encodes a protein containing TOG and XMAP215_CLASP domains, with microtubule plus-end binding, microtubule plus-end polymerase activity, and microtubule destabilizing activity. The gene is associated with mitotic and meiotic processes including spindle assembly and elongation, chromosome movement to the spindle pole, microtubule nucleation by the spindle pole body, and nuclear movement. It localizes to the mitotic spindle pole, spindle microtubules, outer kinetochore, and cytoplasmic microtubule plus-ends. DIS1 is associated with cell cycle progression, particularly the metaphase-anaphase transition, chromosome segregation, nuclear fusion during mating, meiotic recombination, and growth rate. Associations with resistance to chemicals, increased fermentative growth, and decreased lifespan have also been observed. Related genes in other species connect the family to spindle pole body function and microtubule organization.