IDH1 — Aspergillus nidulans FGSC A4

Summary

ANIA_05790 (AnIDH1, IDH1) on chromosome 5 of Aspergillus nidulans FGSC A4 encodes an NAD(+)-specific ICDH with isocitrate dehydrogenase, homoisocitrate dehydrogenase, and 3-isopropylmalate dehydrogenase activities, and binds NAD, magnesium and RNA. The product localises to mitochondria, the mitochondrial lumen and nucleoid, the cytoplasm and cytosol, and is part of the NAD(+)-isocitrate dehydrogenase complex. AnIDH1 is associated with the TCA cycle, glyoxylate cycle, isocitrate metabolism, and the biosynthesis of lysine, L-leucine, acetyl-CoA, CoA and amino acids. Phenotypic associations include decreased colony size, increased cell death, altered lifespan, increased fermentative and decreased respiratory metabolism, increased mitophagy, altered mitochondrial genome maintenance, increased meiotic recombination, and changes in carbon and nitrogen source utilisation, and mating response.