srp1 — Aspergillus nidulans FGSC A4

Summary

ANIA_05802 (srp1) on chromosome 1 of Aspergillus nidulans FGSC A4 encodes an RNA-binding protein of the SRSF/Srp1p_RRM family, also known as SwoK. The product possesses mRNA and RNA binding activity and localises to the nucleus, cytoplasm, nuclear speck and spliceosome complex. The gene is associated with several biological processes, including regulation of alternative mRNA splicing via the spliceosome, mRNA cis splicing, nuclear import, secondary metabolism, ergothioneine anabolism and mycotoxin anabolism. Studies of related genes in other species link the family to reduced virulence and to diseases such as fusarium head blight and rice blast, though these associations are not established for A. nidulans.