elcE — Aspergillus nidulans FGSC A4

Summary

ANIA_06155 (elcE) on chromosome 1 of Aspergillus nidulans FGSC A4 encodes an uncharacterized protein with a FAD-linked oxidoreductase domain and annotated metalloendopeptidase, isomerase, and redox activities, as well as FAD and metal binding. The gene is associated with proteolysis, peptide metabolism, and terpenoid anabolism, and its product localises to the mitochondrial envelope lumen and extracellular space. It is also linked to the protein drtC (C-11) and related genes FUP4 and sdcF. Studies of related genes in other species connect the family to EC 5.5.1.20 and EC 1.1.3.42, and to reduced virulence and unaffected pathogenicity, with associations to early blight of potato and frog-eye leaf spot in solanaceous hosts.