ppoA — Aspergillus nidulans FGSC A4

Summary

ANIA_06320 (ppoA) on chromosome 1 of Aspergillus nidulans FGSC A4 encodes an uncharacterized protein with domains including Ppo-like_N, oxylipin biosynthesis/metabolism, haem peroxidase superfamily, and cytochrome P450 superfamily. It is annotated with multiple enzymatic activities including linoleate 8R-lipoxygenase, 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase, fatty acid peroxidase, peroxidase, dioxygenase, isomerase, oxidoreductase, monooxygenase, and iron and heme binding. The gene is associated with oxylipin, prostaglandin, and phytosphingosine biosynthesis, regulation of hypersensitivity, cell wall thickening, sexual and asexual sporulation, fruiting body formation, carboxylic acid biosynthesis, long-chain fatty acid and sphingolipid metabolism, penicillin metabolism, and hydrogen peroxide catabolism. Related genes in other species link this gene family to altered virulence in aspergillosis and rice blast disease.